Long‐lived dwarf mice: are bile acids a longevity signal?
D Gems - Aging Cell, 2007 - Wiley Online Library
… of long-lived Ghrhr mutant mice reports that increased bile acid … to xenobiotic stress, possibly
contributing to longevity. … and intracellular signaling pathways that control longevity and …
contributing to longevity. … and intracellular signaling pathways that control longevity and …
Host and microbiota metabolic signals in aging and longevity
Y Zhou, G Hu, MC Wang - Nature Chemical Biology, 2021 - nature.com
… Regulation of longevity by bile acids was first observed in Little mice, … The increased levels
of bile acids in these long-lived mice … Increased total bile acid levels have also been observed …
of bile acids in these long-lived mice … Increased total bile acid levels have also been observed …
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
B Gerisch, V Rottiers, D Li, DL Motola… - Proceedings of the …, 2007 - National Acad Sciences
… acid supplementation shortened the lifespan of long-lived daf-… is “proaging” in response to
signals from the dauer pathways. … in long-lived Ames dwarf mice, rate-limiting enzymes for bile …
signals from the dauer pathways. … in long-lived Ames dwarf mice, rate-limiting enzymes for bile …
Molecular physiology of bile acid signaling in health, disease, and aging
A Perino, H Demagny… - Physiological …, 2021 - journals.physiology.org
… /− mice (95), it is still not fully established how FXR signaling keeps hepatic fat deposits in
check. While a comparative study in liver- and intestine-specific Fxr −/− mice demonstrate that …
check. While a comparative study in liver- and intestine-specific Fxr −/− mice demonstrate that …
Gene expression profile of long‐lived Ames dwarf mice and Little mice
D Amador‐Noguez, K Yagi, S Venable… - Aging cell, 2004 - Wiley Online Library
… in lifespan (50% and 25%, respectively) when compared with their wild-type siblings. To gain
further insight into the molecular basis for the extended longevity of these mice, … of signal …
further insight into the molecular basis for the extended longevity of these mice, … of signal …
Longevity is impacted by growth hormone action during early postnatal period
LY Sun, Y Fang, A Patki, JJE Koopman, DB Allison… - Elife, 2017 - elifesciences.org
… GH signaling during development on longevity, we re-examine this issue in both sexes of
normal and longlived mutant mice. … Bile acids induce the expression of the human peroxisome …
normal and longlived mutant mice. … Bile acids induce the expression of the human peroxisome …
Bile acids, chaperones, and mammalian longevity
J Krøll - Rejuvenation Research, 2012 - liebertpub.com
… bile acid–like steroid dafachronic acid extends life span through nuclear receptor
signaling. In the … Long-lived dwarf mice: Are bile acids a longevity signal? Aging Cell 2007;6:421–423. …
signaling. In the … Long-lived dwarf mice: Are bile acids a longevity signal? Aging Cell 2007;6:421–423. …
Alterations in xenobiotic metabolism in the long‐lived Little mice
D Amador‐Noguez, A Dean, W Huang, K Setchell… - Aging cell, 2007 - Wiley Online Library
… instead that bile acids and the primary bile acid receptor Fxr (… with increased longevity in
a variety of long-lived mutants in … Importantly, bile acids also function as signaling molecules …
a variety of long-lived mutants in … Importantly, bile acids also function as signaling molecules …
Regulation of Xenobiotic and Bile Acid Metabolism by the Anti-aging Intervention Calorie Restriction in Mice
Z Fu - 2013 - kuscholarworks.ku.edu
… of BAs as potential longevity signaling molecules, and may … deficiency and longevity is
derived from Laron dwarf mice, … IGF-1 in life span regulation is supported by long-lived IGF-1 …
derived from Laron dwarf mice, … IGF-1 in life span regulation is supported by long-lived IGF-1 …
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
LY Sun, A Spong, WR Swindell, Y Fang, C Hill… - Elife, 2013 - elifesciences.org
… GHRH knockout mice are remarkably long-lived, exhibiting major … KO mice feature
perturbations in a network of signaling pathways … Some studies have shown elevation of bile acids …
perturbations in a network of signaling pathways … Some studies have shown elevation of bile acids …